6 Chile players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Felipe Mora | Portland Timbers | FWD | 1 | 0 | 8 |
| Thomas Gillier | CF Montréal | GK | 0 | 0 | 8 |
| Zidane Yañez | New York City FC | FWD | 0 | 0 | 0 |
| Alexander Aravena | Portland Timbers | FWD | 0 | 0 | 6 |
| Antonio Riquelme | Real Salt Lake | MID | 0 | 0 | 0 |
| Benjamín Kuscevic | Toronto FC | DEF | 0 | 0 | 5 |