9 Chile players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Felipe Mora | Portland Timbers | FWD | 4 | 1 | 13 |
| Alexander Aravena | Portland Timbers | FWD | 1 | 1 | 15 |
| Thomas Gillier | CF Montréal | GK | 0 | 0 | 19 |
| Zidane Yañez | New York City FC | FWD | 0 | 0 | 0 |
| Antonio Riquelme | Real Salt Lake | MID | 0 | 0 | 0 |
| Benjamín Kuscevic | Toronto FC | DEF | 0 | 0 | 10 |
| Paulo Díaz | Atlanta United FC | DEF | 0 | 0 | 3 |
| Gonzalo Tapia | Columbus Crew | FWD | 0 | 0 | 1 |
| Alexis Sánchez | CF Montréal | FWD | 0 | 0 | 3 |