27 Colombia players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Emilio Aristizábal | Toronto FC | FWD | 3 | 0 | 13 |
| Kerwin Vargas | Charlotte FC | FWD | 2 | 3 | 15 |
| Brayan Ceballos | New England Revolution | DEF | 2 | 0 | 8 |
| Santiago Moreno | FC Dallas | FWD | 2 | 1 | 10 |
| Alexis Castillo Manyoma | Colorado Rapids | MID | 1 | 0 | 11 |
| Mauricio Gonzalez | Minnesota United FC | FWD | 1 | 0 | 6 |
| Jeisson Palacios | Nashville SC | DEF | 1 | 0 | 11 |
| Juan Mosquera | Portland Timbers | DEF | 1 | 1 | 3 |
| Édier Ocampo | Vancouver Whitecaps FC | DEF | 1 | 3 | 14 |
| Steven Alzate | Atlanta United FC | MID | 0 | 0 | 7 |
| Brayan Vera | CF Montréal | DEF | 0 | 0 | 12 |
| Nelson Quiñones | Houston Dynamo FC | FWD | 0 | 0 | 0 |
| Carlos Garcés | LA Galaxy | DEF | 0 | 2 | 10 |
| Eddie Segura | LAFC | DEF | 0 | 1 | 13 |
| Jefferson Díaz | Minnesota United FC | DEF | 0 | 2 | 13 |
| James Rodríguez | Minnesota United FC | MID | 0 | 2 | 6 |
| Juan González | New York Red Bulls | DEF | 0 | 0 | 5 |
| Eduard Atuesta | Orlando City SC | MID | 0 | 0 | 11 |
| Iván Angulo | Orlando City SC | MID | 0 | 5 | 15 |
| Geiner Martínez | Philadelphia Union | DEF | 0 | 0 | 7 |
| Diego Chará | Portland Timbers | MID | 0 | 1 | 10 |
| Jimer Fory | Portland Timbers | MID | 0 | 2 | 13 |
| Juan Arias | Real Salt Lake | DEF | 0 | 0 | 0 |
| Andrés Reyes | San Diego FC | DEF | 0 | 0 | 0 |
| Yeimar Gómez | Seattle Sounders FC | DEF | 0 | 0 | 3 |
| José Caicedo | Portland Timbers | MID | 0 | 0 | 7 |
| Julián Bazán | New York Red Bulls | DEF | 0 | 0 | 1 |