| Juan Pablo AngelDP | New York Red Bulls | FW | 62 | 12 | 108 |
| Fredy MonteroDP | Seattle Sounders FC | FW | 60 | 30 | 165 |
| Eduard Atuesta | Los Angeles Football Club | MF | 58 | 61 | 154 |
| Nicolas Molina | FC Dallas | GK | 56 | 8 | 225 |
| Emanuel Suarez | Houston Dynamo FC | DF | 54 | 10 | 230 |
| Raul Vega | Nashville SC | MF | 47 | 12 | 274 |
| Michael BarriosDP | FC Dallas | FW | 46 | 24 | 342 |
| Oscar ParejaDP | FC Dallas | MF | 45 | 34 | 220 |
| Cucho HernandezDP | Columbus Crew | FW | 42 | 15 | 82 |
| Franco Ramos | Philadelphia Union | DF | 42 | 1 | 224 |
| Daniel Jimenez | FC Dallas | MF | 42 | 13 | 182 |
| Ivan Martinez | Minnesota United FC | MF | 39 | 10 | 160 |
| Carlos Cabrera | FC Cincinnati | GK | 38 | 9 | 172 |
| Luis Guerrero | LA Galaxy | FW | 38 | 11 | 152 |
| Carlos Valderrama | Colorado Rapids | MF | 32 | 53 | 315 |
| Sergio Rodriguez | Los Angeles Football Club | MF | 31 | 1 | 182 |
| Leandro Morales | Austin FC | DF | 31 | 5 | 150 |
| Andres Ramirez | Real Salt Lake | MF | 28 | 14 | 140 |
| Matias Herrera | Philadelphia Union | FW | 28 | 14 | 165 |
| Gustavo Garcia | San Jose Earthquakes | MF | 28 | 3 | 126 |
| Gonzalo Vargas | Houston Dynamo FC | DF | 27 | 2 | 120 |
| Enrique Sandoval | Toronto FC | FW | 26 | 5 | 132 |
| Sergio Santos | St. Louis City SC | FW | 25 | 4 | 182 |
| Andres Jimenez | Charlotte FC | DF | 24 | 5 | 174 |
| Fernando Vega | San Diego FC | GK | 24 | 7 | 102 |
| Emiliano Diaz | Vancouver Whitecaps FC | GK | 24 | 9 | 136 |
| Maximiliano Cruz | Charlotte FC | DF | 23 | 10 | 184 |
| Oscar Pereira | Toronto FC | FW | 23 | 10 | 198 |
| Victor Flores | Real Salt Lake | FW | 23 | 1 | 171 |
| Gabriel Jimenez | Minnesota United FC | FW | 22 | 1 | 154 |
| Leandro Barrera | D.C. United | FW | 21 | 11 | 116 |
| Ivan Nunez | Toronto FC | MF | 21 | 1 | 132 |
| Facundo Figueroa | FC Dallas | GK | 21 | 10 | 153 |
| Cristian Barrera | Philadelphia Union | MF | 20 | 1 | 90 |
| Nicolas Torres | Los Angeles Football Club | DF | 19 | 2 | 156 |
| Martin Nunez | St. Louis City SC | DF | 19 | 7 | 78 |
| Pablo Vasquez | Columbus Crew | DF | 17 | 0 | 74 |
| Ricardo Molina | Toronto FC | DF | 17 | 2 | 105 |
| Edgar Ponce | Seattle Sounders FC | MF | 17 | 10 | 114 |
| Cesar Fernandez | San Jose Earthquakes | MF | 16 | 2 | 81 |
| Luis Gonzalez | LA Galaxy | DF | 16 | 6 | 135 |
| Tomas Diaz | Inter Miami CF | DF | 16 | 8 | 107 |
| Thiago Espinoza | Charlotte FC | FW | 16 | 4 | 144 |
| Roberto Delgado | Columbus Crew | MF | 16 | 5 | 108 |
| Cristian Ramirez | Columbus Crew | DF | 16 | 0 | 71 |
| Nicolas Ortiz | Vancouver Whitecaps FC | MF | 15 | 6 | 62 |
| Dairon Asprilla | Portland Timbers | FW | 14 | 24 | 326 |
| Gonzalo Ortiz | Portland Timbers | DF | 14 | 4 | 176 |
| Javier Cardenas | New York City FC | GK | 14 | 2 | 75 |
| Emiliano Vega | FC Cincinnati | FW | 14 | 5 | 217 |
| Javier Aguilar | D.C. United | DF | 14 | 0 | 58 |
| Fernando Paredes | CF Montréal | DF | 14 | 7 | 104 |
| Cesar Hernandez | Charlotte FC | MF | 14 | 5 | 66 |
| Cristian Diaz | Inter Miami CF | FW | 13 | 3 | 68 |
| Victor Cruz | Columbus Crew | FW | 13 | 5 | 64 |
| Diego Chara | Portland Timbers | MF | 12 | 30 | 370 |
| Leandro Paredes | FC Cincinnati | GK | 12 | 3 | 120 |
| Diego Sandoval | Los Angeles Football Club | FW | 12 | 26 | 265 |
| Daniel Morales | Toronto FC | DF | 12 | 9 | 146 |
| Andres Vega | Sporting Kansas City | FW | 12 | 13 | 132 |
| Bruno Diaz | Sporting Kansas City | MF | 11 | 2 | 64 |
| Thiago Paredes | Orlando City SC | DF | 10 | 1 | 44 |
| Emiliano Espinoza | San Diego FC | DF | 10 | 0 | 72 |
| Gonzalo Cabrera | Inter Miami CF | MF | 10 | 2 | 47 |
| Juan Jimenez | Houston Dynamo FC | DF | 10 | 1 | 60 |
| Sebastian Salazar | Toronto FC | GK | 10 | 0 | 141 |
| Diego Rodriguez | Atlanta United FC | FW | 9 | 7 | 81 |
| Maximiliano Torres | Philadelphia Union | MF | 9 | 4 | 115 |
| Rafael Delgado | CF Montréal | MF | 9 | 6 | 192 |
| Alvaro Fernandez | Orlando City SC | MF | 9 | 0 | 149 |
| Alberto Salazar | FC Cincinnati | DF | 9 | 0 | 45 |
| Nicolas Vasquez | Atlanta United FC | MF | 9 | 5 | 73 |
| Ezequiel Medina | Colorado Rapids | DF | 8 | 7 | 198 |
| Alejandro Pereira | Colorado Rapids | MF | 8 | 1 | 129 |
| Daniel Fuentes | Chicago Fire FC | FW | 8 | 3 | 34 |
| Luciano Vargas | St. Louis City SC | DF | 8 | 1 | 32 |
| Roberto Vasquez | Charlotte FC | DF | 8 | 13 | 176 |
| Daniel Cruz | Austin FC | MF | 8 | 3 | 72 |
| Ezequiel Ortiz | Orlando City SC | DF | 7 | 4 | 45 |
| Santiago Torres | Columbus Crew | FW | 7 | 2 | 38 |
| Franco Rodriguez | New York Red Bulls | MF | 7 | 7 | 76 |
| Tomas Acosta | Philadelphia Union | GK | 7 | 7 | 84 |
| Juan Fuentes | D.C. United | FW | 7 | 9 | 123 |
| Bruno Flores | San Diego FC | DF | 7 | 4 | 45 |
| Victor Martinez | Vancouver Whitecaps FC | MF | 7 | 1 | 144 |
| Bruno Cabrera | CF Montréal | DF | 7 | 1 | 31 |
| Martin Rojas | CF Montréal | DF | 6 | 1 | 26 |
| Ricardo Lopez | D.C. United | MF | 6 | 1 | 63 |
| Raul Reyes | Vancouver Whitecaps FC | MF | 6 | 4 | 45 |
| Miguel Garcia | Colorado Rapids | DF | 6 | 4 | 68 |
| Rafael Cabrera | Columbus Crew | DF | 6 | 3 | 108 |
| Enrique Diaz | Austin FC | DF | 6 | 2 | 30 |
| Daniel Paredes | Seattle Sounders FC | MF | 6 | 0 | 64 |
| Maximiliano Lopez | Orlando City SC | GK | 6 | 5 | 72 |
| Ricardo Morales | D.C. United | GK | 6 | 2 | 32 |
| Hector Mendoza | Austin FC | MF | 6 | 3 | 37 |
| Gabriel Vega | Inter Miami CF | MF | 6 | 1 | 45 |
| Ezequiel Hernandez | Charlotte FC | DF | 5 | 1 | 57 |
| Carlos Rodriguez | Charlotte FC | MF | 5 | 3 | 128 |
| Nicolas Nunez | Minnesota United FC | MF | 5 | 2 | 48 |
| Miguel Barrera | Inter Miami CF | FW | 5 | 2 | 44 |
| Luis Espinoza | Portland Timbers | DF | 5 | 1 | 27 |
| Enrique Fuentes | Vancouver Whitecaps FC | MF | 5 | 6 | 160 |
| Gabriel Salazar | New England Revolution | GK | 5 | 3 | 34 |
| Santiago Cardenas | CF Montréal | GK | 5 | 7 | 99 |
| Ezequiel Espinoza | FC Cincinnati | DF | 4 | 3 | 31 |
| Luis Espinoza | FC Dallas | DF | 4 | 1 | 32 |
| Ricardo Ortiz | New York City FC | MF | 4 | 1 | 26 |
| Manuel Suarez | Austin FC | DF | 4 | 3 | 32 |
| Sebastian Delgado | Colorado Rapids | DF | 4 | 4 | 41 |
| Gabriel Ortiz | San Jose Earthquakes | DF | 4 | 5 | 66 |
| Luciano Delgado | Chicago Fire FC | DF | 4 | 0 | 45 |
| Santiago Guerrero | Sporting Kansas City | MF | 4 | 1 | 64 |
| Andres RamirezDP | Vancouver Whitecaps FC | GK | 3 | 4 | 126 |
| Santiago Suarez | San Jose Earthquakes | DF | 3 | 2 | 30 |
| Facundo Rios | FC Cincinnati | FW | 3 | 0 | 18 |
| Jorge Salazar | New York City FC | GK | 3 | 2 | 57 |
| Carlos Espinoza | Seattle Sounders FC | MF | 3 | 4 | 45 |
| Alvaro Pereira | Seattle Sounders FC | MF | 3 | 1 | 13 |
| Alvaro Mendoza | Columbus Crew | DF | 3 | 2 | 34 |
| Luciano Paredes | Vancouver Whitecaps FC | DF | 2 | 0 | 37 |
| Franco Gonzalez | Sporting Kansas City | MF | 2 | 0 | 104 |
| Bruno Fuentes | D.C. United | FW | 2 | 1 | 53 |
| Ezequiel Diaz | San Diego FC | FW | 2 | 12 | 168 |
| Matias Hernandez | Los Angeles Football Club | DF | 2 | 0 | 10 |
| Emiliano Valencia | Los Angeles Football Club | DF | 2 | 1 | 175 |
| Ricardo Soto | Orlando City SC | FW | 2 | 2 | 20 |
| Marco Ramos | CF Montréal | DF | 2 | 5 | 155 |
| Santiago Pereira | CF Montréal | DF | 2 | 7 | 88 |
| Ezequiel Ramos | D.C. United | FW | 2 | 0 | 18 |
| Sebastian Torres | FC Cincinnati | MF | 2 | 0 | 34 |
| Jorge Fuentes | Sporting Kansas City | FW | 2 | 0 | 66 |
| Matias Figueroa | Atlanta United FC | MF | 2 | 3 | 51 |
| Oscar Aguilar | Nashville SC | GK | 2 | 0 | 45 |
| Emiliano Silva | Chicago Fire FC | MF | 2 | 4 | 43 |
| Victor Cruz | Nashville SC | FW | 2 | 2 | 33 |
| Alberto Paredes | Charlotte FC | FW | 1 | 0 | 0 |
| Diego Salazar | FC Cincinnati | GK | 1 | 4 | 44 |
| Gustavo Vega | Sporting Kansas City | MF | 1 | 0 | 10 |
| Sergio Lopez | Colorado Rapids | DF | 1 | 7 | 120 |
| Sebastian Pereira | Nashville SC | DF | 1 | 2 | 23 |
| Franco Gutierrez | Los Angeles Football Club | FW | 1 | 0 | 66 |
| Ricardo Valencia | San Jose Earthquakes | DF | 1 | 3 | 31 |
| Jorge Barrera | New York City FC | FW | 1 | 0 | 18 |
| Fernando Paredes | Los Angeles Football Club | FW | 1 | 8 | 84 |
| Ricardo Fuentes | Toronto FC | DF | 1 | 1 | 26 |
| Ignacio Rios | Minnesota United FC | DF | 1 | 1 | 17 |
| Manuel Suarez | Nashville SC | DF | 1 | 1 | 30 |
| Ezequiel Reyes | San Jose Earthquakes | FW | 1 | 1 | 17 |
| Matias Cabrera | Toronto FC | GK | 1 | 2 | 60 |
| Luis Fernandez | Austin FC | MF | 1 | 1 | 15 |
| Alvaro Barrera | Orlando City SC | FW | 1 | 0 | 18 |
| Juan Cabrera | Orlando City SC | MF | 1 | 5 | 72 |
| Roberto Lopez | New England Revolution | FW | 1 | 9 | 121 |
| Raul Mendoza | Chicago Fire FC | MF | 0 | 3 | 69 |
| Manuel Espinoza | Houston Dynamo FC | MF | 0 | 7 | 112 |
| Andres Flores | Orlando City SC | FW | 0 | 0 | 0 |
| Cristian Paredes | San Diego FC | DF | 0 | 2 | 21 |
| Diego Lopez | New York City FC | DF | 0 | 5 | 60 |
| Ricardo Ramirez | Nashville SC | MF | 0 | 2 | 36 |
| Thiago Herrera | Vancouver Whitecaps FC | GK | 0 | 0 | 18 |
| Emiliano Gonzalez | Sporting Kansas City | DF | 0 | 0 | 19 |
| Ivan Paredes | Toronto FC | MF | 0 | 1 | 14 |
| Jorge Vargas | FC Cincinnati | DF | 0 | 11 | 198 |
| Ezequiel Rojas | Inter Miami CF | DF | 0 | 2 | 46 |