12 Denmark players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Marcus Ingvartsen | San Diego FC | FWD | 11 | 4 | 15 |
| Anders Dreyer | San Diego FC | MID | 6 | 9 | 15 |
| Philip Zinckernagel | Chicago Fire FC | FWD | 5 | 7 | 14 |
| Mikkel Desler | Austin FC | DEF | 1 | 0 | 9 |
| Erik Sviatchenko | Houston Dynamo FC | DEF | 1 | 0 | 8 |
| Japhet Sery | Philadelphia Union | DEF | 1 | 0 | 10 |
| Nico Hansen | Colorado Rapids | GK | 0 | 0 | 6 |
| Malte Amundsen | Columbus Crew | DEF | 0 | 1 | 11 |
| Lukas Engel | Real Salt Lake | DEF | 0 | 0 | 9 |
| Osvald Søe | San Diego FC | DEF | 0 | 0 | 6 |
| Jeppe Tverskov | San Diego FC | MID | 0 | 2 | 10 |
| Luca Costabile | Toronto FC | DEF | 0 | 0 | 0 |