15 England players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Calvin Harris | Sporting Kansas City | FWD | 3 | 5 | 22 |
| Matthew Longstaff | CF Montréal | MID | 2 | 3 | 22 |
| Osaze Urhoghide | FC Dallas | DEF | 1 | 1 | 18 |
| Nathan Byrne | Charlotte FC | DEF | 0 | 0 | 19 |
| Harry Toffolo | Charlotte FC | DEF | 0 | 3 | 13 |
| Ashley Westwood | Charlotte FC | MID | 0 | 0 | 1 |
| Tyger Smalls | Charlotte FC | FWD | 0 | 0 | 11 |
| Jack Elliott | Chicago Fire FC | DEF | 0 | 2 | 19 |
| Rob Holding | Colorado Rapids | DEF | 0 | 0 | 20 |
| Jonathan Bond | Houston Dynamo FC | GK | 0 | 0 | 22 |
| Sam Surridge | Nashville SC | FWD | 0 | 1 | 1 |
| Alex Mighten | San Diego FC | FWD | 0 | 2 | 13 |
| Noel Buck | San Jose Earthquakes | MID | 0 | 0 | 1 |
| Andre Dozzell | D.C. United | MID | 0 | 0 | 7 |
| Jack Harrison | New England Revolution | FWD | 0 | 5 | 5 |