16 Germany players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Hany Mukhtar | Nashville SC | MID | 6 | 5 | 15 |
| Marco Reus | LA Galaxy | MID | 4 | 5 | 16 |
| Timo Werner | San Jose Earthquakes | FWD | 4 | 5 | 7 |
| Marcel Hartel | St. Louis CITY SC | MID | 4 | 2 | 13 |
| Thomas Müller | Vancouver Whitecaps FC | FWD | 4 | 4 | 12 |
| Lawrence Ennali | Houston Dynamo FC | FWD | 3 | 2 | 14 |
| Eduard Löwen | St. Louis CITY SC | MID | 2 | 1 | 8 |
| Erik Thommy | LA Galaxy | MID | 1 | 0 | 10 |
| Morris Duggan | Minnesota United FC | DEF | 1 | 0 | 15 |
| Timo Baumgartl | St. Louis CITY SC | DEF | 1 | 0 | 15 |
| Fabian Herbers | CF Montréal | FWD | 0 | 0 | 5 |
| Robert Voloder | New York Red Bulls | DEF | 0 | 1 | 8 |
| Noel Caliskan | Real Salt Lake | MID | 0 | 3 | 14 |
| Benjamin Lundt | St. Louis CITY SC | GK | 0 | 0 | 2 |
| Cedric Teuchert | St. Louis CITY SC | FWD | 0 | 1 | 10 |
| Sebastian Schonlau | Vancouver Whitecaps FC | DEF | 0 | 0 | 1 |