16 Ghana players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Prince Owusu | CF Montréal | FWD | 13 | 6 | 21 |
| Joseph Paintsil | LA Galaxy | FWD | 5 | 4 | 19 |
| Shakur Mohammed | Nashville SC | MID | 3 | 0 | 12 |
| Morrison Agyemang | Charlotte FC | DEF | 2 | 0 | 18 |
| Maxwell Woledzi | Nashville SC | DEF | 2 | 1 | 22 |
| Kwadwo Opoku | CF Montréal | FWD | 1 | 0 | 5 |
| Lalas Abubakar | FC Dallas | DEF | 1 | 0 | 3 |
| Ronald Donkor | New York Red Bulls | MID | 1 | 6 | 21 |
| Mohammed Sofo | New York Red Bulls | FWD | 1 | 1 | 15 |
| Ezekiel Alladoh | Philadelphia Union | FWD | 1 | 1 | 19 |
| Ali Fadal | Colorado Rapids | MID | 0 | 0 | 0 |
| William Kumado | San Diego FC | DEF | 0 | 0 | 2 |
| Emmanuel Boateng | San Diego FC | MID | 0 | 0 | 0 |
| Manu Duah | San Diego FC | MID | 0 | 1 | 21 |
| Kwaku Agyabeng | Sporting Kansas City | MID | 0 | 0 | 13 |
| Joshua Yaro | St. Louis CITY SC | DEF | 0 | 0 | 0 |