5 Honduras players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Joseph Rosales | Austin FC | MID | 0 | 0 | 8 |
| David Ruiz | Inter Miami CF | MID | 0 | 0 | 2 |
| Andy Nájar | Nashville SC | DEF | 0 | 2 | 7 |
| Bryan Acosta | Nashville SC | MID | 0 | 0 | 2 |
| Johann Chirinos | Columbus Crew | MID | 0 | 0 | 0 |