| Diego Rojas | New England Revolution | FW | 50 | 6 | 225 |
| Thiago Hernandez | San Diego FC | DF | 41 | 1 | 168 |
| Edgar Santos | San Jose Earthquakes | DF | 38 | 25 | 294 |
| Yordy Reyna | Vancouver Whitecaps FC | FW | 34 | 16 | 50 |
| Luciano Ramos | Chicago Fire FC | MF | 31 | 5 | 162 |
| Rafael Lopez | Colorado Rapids | DF | 26 | 11 | 122 |
| Luis Nunez | Inter Miami CF | DF | 23 | 8 | 150 |
| Roberto Barrera | Philadelphia Union | DF | 23 | 2 | 96 |
| Santiago Nunez | Los Angeles Football Club | MF | 21 | 0 | 148 |
| Gonzalo Vargas | San Jose Earthquakes | MF | 21 | 5 | 102 |
| Gabriel Suarez | St. Louis City SC | FW | 21 | 1 | 136 |
| Thiago Cabrera | Atlanta United FC | DF | 21 | 7 | 153 |
| Santiago Pereira | Colorado Rapids | DF | 19 | 12 | 153 |
| Maximiliano Herrera | San Jose Earthquakes | MF | 17 | 1 | 150 |
| Cristian Acosta | Nashville SC | MF | 17 | 0 | 69 |
| Andres Molina | Nashville SC | DF | 17 | 14 | 140 |
| Raul Rodriguez | Austin FC | FW | 16 | 6 | 144 |
| Sebastian Herrera | Austin FC | DF | 16 | 7 | 102 |
| Franco Diaz | Nashville SC | MF | 15 | 7 | 136 |
| Gustavo Acosta | Inter Miami CF | MF | 14 | 7 | 88 |
| Rodrigo Herrera | Philadelphia Union | FW | 14 | 3 | 82 |
| Ivan Lopez | Columbus Crew | MF | 14 | 7 | 81 |
| Diego Delgado | St. Louis City SC | MF | 10 | 0 | 62 |
| Martin Castillo | FC Dallas | GK | 10 | 5 | 78 |
| Martin Herrera | New England Revolution | FW | 9 | 6 | 63 |
| Maximiliano Pereira | New York Red Bulls | MF | 9 | 4 | 40 |
| Gustavo Espinoza | CF Montréal | MF | 9 | 7 | 90 |
| Roberto Herrera | LA Galaxy | DF | 9 | 4 | 51 |
| Carlos Reyes | FC Cincinnati | FW | 8 | 8 | 80 |
| Alejandro Jimenez | Houston Dynamo FC | MF | 8 | 0 | 51 |
| Emiliano Ramirez | New England Revolution | MF | 7 | 6 | 125 |
| Leandro Rodriguez | FC Cincinnati | DF | 7 | 4 | 46 |
| Maximiliano Herrera | Austin FC | GK | 7 | 5 | 64 |
| Hector Castillo | Seattle Sounders FC | GK | 7 | 3 | 245 |
| Gabriel Garcia | Nashville SC | GK | 6 | 0 | 34 |
| Fernando Fernandez | D.C. United | DF | 6 | 3 | 90 |
| Rodrigo Valencia | Atlanta United FC | DF | 6 | 1 | 76 |
| Tomas Cruz | St. Louis City SC | DF | 6 | 12 | 152 |
| Luciano Cabrera | San Jose Earthquakes | MF | 5 | 1 | 21 |
| Jorge Cardenas | CF Montréal | FW | 5 | 1 | 72 |
| Cristian Pereira | D.C. United | MF | 5 | 2 | 31 |
| Pablo Ramos | CF Montréal | FW | 5 | 1 | 30 |
| Alvaro Cardenas | Colorado Rapids | FW | 5 | 1 | 34 |
| Alberto Hernandez | Nashville SC | GK | 4 | 2 | 21 |
| Gustavo Rojas | New England Revolution | MF | 4 | 0 | 18 |
| Rodrigo Navarro | Minnesota United FC | MF | 4 | 0 | 40 |
| Gonzalo Valencia | LA Galaxy | MF | 4 | 0 | 28 |
| Hector Molina | LA Galaxy | MF | 4 | 1 | 33 |
| Santiago Rios | Toronto FC | FW | 3 | 6 | 60 |
| Sebastian Rodriguez | Minnesota United FC | MF | 3 | 4 | 56 |
| Edgar Ponce | CF Montréal | MF | 3 | 12 | 156 |
| Bruno Navarro | Orlando City SC | DF | 3 | 1 | 27 |
| Cristian Cruz | Los Angeles Football Club | DF | 3 | 1 | 84 |
| Ricardo Herrera | FC Cincinnati | MF | 2 | 2 | 24 |
| Edgar Espinoza | San Diego FC | MF | 2 | 0 | 13 |
| Cesar Castillo | San Jose Earthquakes | GK | 2 | 0 | 10 |
| Luciano Rodriguez | Atlanta United FC | FW | 1 | 2 | 25 |
| Sebastian Gutierrez | Houston Dynamo FC | FW | 1 | 3 | 50 |
| Gabriel Torres | Los Angeles Football Club | DF | 1 | 0 | 31 |
| Matias Santos | Columbus Crew | DF | 0 | 0 | 28 |
| Facundo Espinoza | Los Angeles Football Club | DF | 0 | 7 | 70 |
| Carlos Mendoza | FC Dallas | MF | 0 | 0 | 32 |
| Maximiliano Castillo | Inter Miami CF | MF | 0 | 4 | 45 |
| Enrique Vega | Philadelphia Union | MF | 0 | 2 | 114 |
| Ezequiel Martinez | D.C. United | MF | 0 | 7 | 72 |
| Facundo Hernandez | LA Galaxy | DF | 0 | 0 | 13 |
| Maximiliano Hernandez | Real Salt Lake | GK | 0 | 1 | 63 |