6 Portugal players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| David Da Costa | Portland Timbers | MID | 1 | 0 | 5 |
| Pedro Amador | Atlanta United FC | DEF | 0 | 0 | 5 |
| Leonardo Barroso | Chicago Fire FC | DEF | 0 | 0 | 7 |
| André Franco | Chicago Fire FC | MID | 0 | 0 | 0 |
| André Gomes | Columbus Crew | MID | 0 | 0 | 5 |
| Rúben Ismael | LA Galaxy | MID | 0 | 0 | 2 |