8 Serbia players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Dejan Joveljic | Sporting Kansas City | FWD | 6 | 2 | 14 |
| Mateja Djordjevic | Austin FC | DEF | 0 | 0 | 2 |
| Viktor Radojevic | Chicago Fire FC | DEF | 0 | 0 | 6 |
| Novak Micovic | LA Galaxy | GK | 0 | 0 | 4 |
| Strahinja Tanasijevic | New York City FC | DEF | 0 | 0 | 3 |
| Jovan Lukic | Philadelphia Union | MID | 0 | 1 | 14 |
| Nikola Petkovic | Seattle Sounders FC | MID | 0 | 0 | 4 |
| Ranko Veselinovic | Vancouver Whitecaps FC | DEF | 0 | 0 | 2 |