4 South Africa players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Puso Dithejane | Chicago Fire FC | DEF | 0 | 0 | 1 |
| Mbekezeli Mbokazi | Chicago Fire FC | DEF | 0 | 0 | 4 |
| Bongokuhle Hlongwane | Minnesota United FC | FWD | 0 | 0 | 3 |
| Olwethu Makhanya | Philadelphia Union | DEF | 0 | 0 | 3 |