8 South Africa players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Puso Dithejane | Chicago Fire FC | DEF | 2 | 1 | 17 |
| Mbekezeli Mbokazi | Chicago Fire FC | DEF | 0 | 0 | 12 |
| Bongokuhle Hlongwane | Minnesota United FC | FWD | 0 | 0 | 15 |
| Olwethu Makhanya | Philadelphia Union | DEF | 0 | 0 | 13 |
| Tsiki Ntsabeleng | FC Dallas | MID | 0 | 0 | 0 |
| Cassius Mailula | Toronto FC | FWD | 0 | 0 | 0 |
| Tylon Smith | New England Revolution | DEF | 0 | 0 | 0 |
| Lyle Foster | Houston Dynamo FC | FWD | 0 | 0 | 0 |