19 Spain players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Sergi Solans | Real Salt Lake | FWD | 9 | 3 | 20 |
| Carles Gil | New England Revolution | MID | 8 | 8 | 22 |
| Manu García | Sporting Kansas City | MID | 2 | 5 | 18 |
| Brais Méndez | Columbus Crew | MID | 2 | 1 | 5 |
| Ilie Sánchez | Austin FC | MID | 1 | 1 | 18 |
| Iván Jaime | CF Montréal | MID | 1 | 2 | 12 |
| Sergio Reguilón | Inter Miami CF | DEF | 1 | 0 | 12 |
| Sergi Palencia | LAFC | DEF | 1 | 1 | 9 |
| Loic Williams | Colorado Rapids | DEF | 1 | 0 | 7 |
| Juan Berrocal | Atlanta United FC | DEF | 0 | 0 | 9 |
| Sergio Santos | Atlanta United FC | DEF | 0 | 0 | 5 |
| Pep Biel | Charlotte FC | MID | 0 | 0 | 1 |
| Ricard Puig | LA Galaxy | MID | 0 | 0 | 0 |
| Adrián Marín | Orlando City SC | DEF | 0 | 3 | 18 |
| Jesús Barea | Real Salt Lake | FWD | 0 | 0 | 3 |
| Alonso Coello | Toronto FC | MID | 0 | 3 | 22 |
| Jorge Alastuey | Austin FC | MID | 0 | 0 | 5 |
| Arnau Farnós | New York City FC | FWD | 0 | 0 | 8 |
| Sergi Roberto | LA Galaxy | MID | 0 | 0 | 1 |