5 Ukraine players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Hennadii Synchuk | CF Montréal | FWD | 1 | 0 | 8 |
| Oleksandr Svatok | Austin FC | DEF | 0 | 0 | 14 |
| Ivan Losenko | CF Montréal | MID | 0 | 0 | 0 |
| Yevhen Cheberko | Columbus Crew | DEF | 0 | 0 | 3 |
| Artem Smolyakov | LAFC | DEF | 0 | 0 | 5 |