Complete 2010 Major League Soccer regular season standings across 16 teams. LA Galaxy led the league with 59 points.
| # | Team | GP | W | D | L | GF | GA | GD | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Red Bull New York | 30 | 15 | 6 | 9 | 38 | 29 | +9 | 51 |
| 2 | Columbus Crew | 30 | 14 | 8 | 8 | 40 | 34 | +6 | 50 |
| 3 | Sporting Kansas City | 30 | 11 | 6 | 13 | 36 | 35 | +1 | 39 |
| 4 | Chicago Fire FC | 30 | 9 | 9 | 12 | 37 | 38 | -1 | 36 |
| 5 | Toronto FC | 30 | 9 | 8 | 13 | 33 | 41 | -8 | 35 |
| 6 | New England Revolution | 30 | 9 | 5 | 16 | 32 | 50 | -18 | 32 |
| 7 | Philadelphia Union | 30 | 8 | 7 | 15 | 35 | 49 | -14 | 31 |
| 8 | D.C. United | 30 | 6 | 4 | 20 | 21 | 47 | -26 | 22 |
Line indicates playoff qualification cutoff
| # | Team | GP | W | D | L | GF | GA | GD | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | LA Galaxy | 30 | 18 | 5 | 7 | 44 | 26 | +18 | 59 |
| 2 | Real Salt Lake | 30 | 15 | 11 | 4 | 45 | 20 | +25 | 56 |
| 3 | FC Dallas | 30 | 12 | 14 | 4 | 42 | 28 | +14 | 50 |
| 4 | Seattle Sounders FC | 30 | 14 | 6 | 10 | 39 | 35 | +4 | 48 |
| 5 | Colorado Rapids | 30 | 12 | 10 | 8 | 44 | 32 | +12 | 46 |
| 6 | San Jose Earthquakes | 30 | 13 | 7 | 10 | 34 | 33 | +1 | 46 |
| 7 | Houston Dynamo FC | 30 | 9 | 6 | 15 | 40 | 49 | -9 | 33 |
| 8 | Chivas USA | 30 | 8 | 4 | 18 | 31 | 45 | -14 | 28 |
Line indicates playoff qualification cutoff
| # | Team | GP | W | D | L | GF | GA | GD | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | LA Galaxy | 30 | 18 | 5 | 7 | 44 | 26 | +18 | 59 |
| 2 | Real Salt Lake | 30 | 15 | 11 | 4 | 45 | 20 | +25 | 56 |
| 3 | Red Bull New York | 30 | 15 | 6 | 9 | 38 | 29 | +9 | 51 |
| 4 | FC Dallas | 30 | 12 | 14 | 4 | 42 | 28 | +14 | 50 |
| 5 | Columbus Crew | 30 | 14 | 8 | 8 | 40 | 34 | +6 | 50 |
| 6 | Seattle Sounders FC | 30 | 14 | 6 | 10 | 39 | 35 | +4 | 48 |
| 7 | Colorado Rapids | 30 | 12 | 10 | 8 | 44 | 32 | +12 | 46 |
| 8 | San Jose Earthquakes | 30 | 13 | 7 | 10 | 34 | 33 | +1 | 46 |
| 9 | Sporting Kansas City | 30 | 11 | 6 | 13 | 36 | 35 | +1 | 39 |
| 10 | Chicago Fire FC | 30 | 9 | 9 | 12 | 37 | 38 | -1 | 36 |
| 11 | Toronto FC | 30 | 9 | 8 | 13 | 33 | 41 | -8 | 35 |
| 12 | Houston Dynamo FC | 30 | 9 | 6 | 15 | 40 | 49 | -9 | 33 |
| 13 | New England Revolution | 30 | 9 | 5 | 16 | 32 | 50 | -18 | 32 |
| 14 | Philadelphia Union | 30 | 8 | 7 | 15 | 35 | 49 | -14 | 31 |
| 15 | Chivas USA | 30 | 8 | 4 | 18 | 31 | 45 | -14 | 28 |
| 16 | D.C. United | 30 | 6 | 4 | 20 | 21 | 47 | -26 | 22 |