5 Cameroon players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Eric Maxim Choupo-Moting | New York Red Bulls | FWD | 1 | 0 | 7 |
| Tah Anunga | FC Cincinnati | MID | 0 | 0 | 3 |
| Axel Essengue | LA Galaxy | DEF | 0 | 0 | 0 |
| Olivier Mbaizo | Philadelphia Union | DEF | 0 | 0 | 0 |
| Nouhou Tolo | Seattle Sounders FC | DEF | 0 | 0 | 7 |