8 Nigeria players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Alhassan Yusuf | New England Revolution | MID | 5 | 1 | 22 |
| Ibrahim Aliyu | Columbus Crew | FWD | 2 | 0 | 15 |
| Hamzat Ojediran | Colorado Rapids | MID | 1 | 0 | 20 |
| Victor Olatunji | Real Salt Lake | FWD | 1 | 0 | 17 |
| Sunusi Ibrahim | CF Montréal | FWD | 0 | 0 | 0 |
| Obinna Nwobodo | FC Cincinnati | MID | 0 | 1 | 17 |
| Nonso Adimabua | San Jose Earthquakes | FWD | 0 | 1 | 2 |
| Daniel Job | FC Dallas | MID | 0 | 0 | 0 |