| Chidi Ba | New York Red Bulls | MF | 62 | 23 | 280 |
| Omar Ntcham | Minnesota United FC | FW | 52 | 19 | 210 |
| Obafemi MartinsDP | Seattle Sounders FC | FW | 40 | 22 | 75 |
| Yaw Malong | LA Galaxy | FW | 36 | 3 | 145 |
| William Owusu | San Jose Earthquakes | DF | 36 | 10 | 215 |
| George Kone | Colorado Rapids | GK | 35 | 0 | 140 |
| Solomon Boateng | Nashville SC | DF | 33 | 12 | 154 |
| Kojo Toko | Inter Miami CF | DF | 32 | 1 | 162 |
| Fanendo AdiDP | Portland Timbers | FW | 31 | 17 | 189 |
| Ifeanyi Choupo | Chicago Fire FC | MF | 27 | 8 | 146 |
| Patrick Choupo | Nashville SC | DF | 26 | 6 | 138 |
| Papa Chukwueze | Charlotte FC | DF | 25 | 5 | 108 |
| Eric Onyeka | New England Revolution | MF | 24 | 8 | 185 |
| Ike Mbeumo | Columbus Crew | GK | 23 | 5 | 105 |
| Paul Diallo | Portland Timbers | MF | 22 | 8 | 93 |
| Yaw Toko | Atlanta United FC | FW | 21 | 2 | 92 |
| Abdoulaye Ekambi | Colorado Rapids | DF | 20 | 9 | 95 |
| Bakary Diop | San Diego FC | MF | 19 | 8 | 85 |
| Yaw Kone | Minnesota United FC | DF | 18 | 7 | 88 |
| Boubacar Appiah | Orlando City SC | DF | 17 | 2 | 79 |
| Moussa Mensah | New York Red Bulls | FW | 17 | 7 | 190 |
| Moussa Onyeka | Sporting Kansas City | MF | 17 | 3 | 84 |
| Kwesi Chukwueze | Toronto FC | FW | 17 | 15 | 189 |
| William Asante | St. Louis City SC | MF | 16 | 1 | 72 |
| Kwesi Aboubakar | Inter Miami CF | MF | 16 | 1 | 88 |
| Daniel Toko | New York City FC | FW | 16 | 10 | 100 |
| Emmanuel Traore | Vancouver Whitecaps FC | MF | 16 | 2 | 87 |
| Cheikh Ondoua | San Jose Earthquakes | MF | 16 | 5 | 68 |
| Samuel Kone | Los Angeles Football Club | FW | 15 | 8 | 84 |
| Lamine Boateng | Austin FC | DF | 14 | 2 | 62 |
| Solomon Iheanacho | Orlando City SC | FW | 14 | 5 | 78 |
| Abdoulaye Amoah | Atlanta United FC | DF | 14 | 5 | 147 |
| Souleymane Ekambi | Philadelphia Union | DF | 14 | 2 | 60 |
| Samuel Kone | San Diego FC | GK | 13 | 5 | 77 |
| Samuel Asante | FC Cincinnati | MF | 13 | 1 | 109 |
| Ifeanyi Ndidi | Houston Dynamo FC | MF | 12 | 8 | 118 |
| Kwame Chukwueze | FC Dallas | GK | 11 | 3 | 58 |
| William Appiah | FC Cincinnati | MF | 10 | 6 | 64 |
| Ifeanyi Ekambi | Philadelphia Union | DF | 9 | 0 | 36 |
| Papa Camara | New England Revolution | DF | 9 | 9 | 132 |
| Dele Iheanacho | Philadelphia Union | MF | 9 | 10 | 105 |
| Papa Iheanacho | CF Montréal | MF | 8 | 5 | 73 |
| Peter Malong | New England Revolution | MF | 8 | 2 | 60 |
| Kojo Chukwueze | Inter Miami CF | MF | 8 | 2 | 42 |
| Emmanuel Mbeumo | Vancouver Whitecaps FC | GK | 8 | 1 | 80 |
| Benjamin Asante | Orlando City SC | DF | 7 | 0 | 100 |
| Moses Eze | Portland Timbers | DF | 7 | 1 | 30 |
| William Appiah | Los Angeles Football Club | DF | 7 | 3 | 47 |
| Amadou Boateng | San Jose Earthquakes | DF | 6 | 2 | 66 |
| Abraham Appiah | Real Salt Lake | FW | 6 | 5 | 232 |
| Obinna Ekambi | Orlando City SC | GK | 5 | 2 | 22 |
| Moses Osimhen | Minnesota United FC | MF | 5 | 2 | 124 |
| Kwame Onyeka | Los Angeles Football Club | FW | 5 | 5 | 69 |
| Kofi Appiah | FC Cincinnati | DF | 5 | 3 | 64 |
| Kwesi Ndiaye | Chicago Fire FC | FW | 4 | 3 | 74 |
| Moussa Sow | San Diego FC | DF | 4 | 3 | 63 |
| Ousmane Malong | Colorado Rapids | GK | 4 | 0 | 87 |
| Benjamin Amoah | New York Red Bulls | DF | 4 | 3 | 58 |
| Abraham Sow | Colorado Rapids | DF | 4 | 1 | 22 |
| Abdoulaye Anguissa | New York Red Bulls | MF | 4 | 5 | 130 |
| David Traore | Houston Dynamo FC | FW | 4 | 3 | 53 |
| Ibrahim Camara | CF Montréal | MF | 3 | 3 | 60 |
| Bakary Mbeumo | San Diego FC | DF | 3 | 1 | 15 |
| Bakary Appiah | D.C. United | FW | 3 | 3 | 44 |
| Ibrahim Toko | Philadelphia Union | DF | 3 | 4 | 125 |
| Kwesi Ekambi | D.C. United | MF | 3 | 2 | 60 |
| Joseph Ekambi | CF Montréal | DF | 3 | 1 | 22 |
| Obinna Anguissa | San Jose Earthquakes | FW | 3 | 0 | 15 |
| Obinna Ekambi | Inter Miami CF | MF | 2 | 0 | 21 |
| Cheikh Malong | San Jose Earthquakes | FW | 2 | 2 | 40 |
| Francis Agyemang | Portland Timbers | FW | 2 | 2 | 27 |
| Samuel Boateng | Minnesota United FC | MF | 2 | 1 | 14 |
| Moses Toure | Los Angeles Football Club | FW | 2 | 0 | 182 |
| Francis Onyeka | FC Dallas | DF | 1 | 4 | 160 |
| George Appiah | New York Red Bulls | DF | 1 | 9 | 165 |
| Amadou Ba | FC Dallas | DF | 1 | 1 | 18 |
| Mamadou Iheanacho | Minnesota United FC | GK | 0 | 0 | 10 |
| Samuel Onuoha | Columbus Crew | DF | 0 | 4 | 78 |