5 Paraguay players across Major League Soccer.
| Player | Team | Pos | Goals | Assists | Apps |
|---|---|---|---|---|---|
| Matías Galarza | Atlanta United FC | MID | 0 | 1 | 5 |
| Miguel Almirón | Atlanta United FC | FWD | 0 | 3 | 7 |
| Gilberto Flores | FC Cincinnati | DEF | 0 | 0 | 5 |
| Braian Ojeda | Orlando City SC | MID | 0 | 0 | 8 |
| Andrés Cubas | Vancouver Whitecaps FC | MID | 0 | 2 | 6 |